Interestingly, melatonin’s actions are purported to be mediated through connection with the proteasomal degradation 35, 36 and an increase in p300 expression 37 as demonstrated in other cell types.
If melatonin has a general effect on proteasomes, it would be expected to modulate cellular levels of a number of signal transducing proteins including p53, VEGF, Bcl-2, BAX and AKT1, all of which are influenced by both melatonin and the ubiquitin–proteasome system.
Melatonin and ubiquitin: what’s the connection? Vriend, Jerry; Reiter, Russel 2014-06-12 00:00:00 Melatonin has been widely studied for its role in photoperiodism in seasonal breeders; it is also a …
Veröffentlicht in:Cellular and Molecular Life Sciences · 2014Autoren:Jerry Vriend · Russel J ReiterZugehörigkeit: University of Manitoba · University of Texas Health Science Center at San AntonioÜber:Calmodulin · Signal transduction · Protein kinase B · Mitochondrion · VEGF receptors
Melatonin has been widely studied for its role in photoperiodism in seasonal breeders; it is also a potent antioxidant. Ubiquitin, a protein also widespread in living cells, contributes to many cellular events, although the most well known is that of tagging proteins for destruction by the proteasome.
Considering the fact that the degradation of most cellular proteins are regulated by the ubiquitin-proteasome system , , it can be fairly assumed (but not generally recognized) that many of the proteins influenced by melatonin, are likely regulated through their …
Melatonin is regarded by many as a sleep aid, something to take on nights when insomnia is keeping them from getting a good night’s rest. But did you know the hormone also plays a key role in your body?
UBIQUITINATION #4: UBIQUITIN’S CONNECTION TO LIGHT. READERS SUMMARY: 1. If you do not get enough sleep, can low stress become high stress just by changing the light we live under? 2. If you live in a city, especially in a high rise, can a paleo diet become a SAD? Blue light is what destroys DHA quickest, and in turn, lowers melatonin, and
There is an increasing understanding that melatonin and the ubiquitin/proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes, cell cycle and many other cellular functions.
These actions of melatonin could be interpreted as being mediated by the ubiquitin ligases SCF(B-TrCP) and Keap-Cul3-Rbx, or as an inhibitory effect on proteasomes.
title = “Melatonin, bone regulation and the ubiquitin-proteasome connection: A review”, abstract = “Recently, investigators have shown that ubiquitin-proteasome-mediated protein degradation is critical in regulating the balance between bone formation and bone resorption.